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The alteration of glutamate in CSF, blood and brain tissue related to synthesis, metabolism and reuptake into neuronal or glial cells is linked to decreased glutamate in the subgenual of anterior cingulate cortex associated with reduced connectivity with insula and decreased BOLD response to emotional stimuli in MDD patients (139)

Association between diet quality and index of non-alcoholic steatohepatitis in a large population of people with type 2 diabetes: data from the TOSCA.IT study

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Nanocarrier-based drug delivery systems have therefore emerged as a promising strategy to overcome these translational barriers

As a critical molecule in cellular energy metabolism and DNA repair, insufficient NAD+ directly triggers a series of metabolic abnormalities, including impaired mitochondrial function, reduced energy metabolism efficiency, and weakened DNA repair capacity