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However, their pathophysiology is likely multifactorial, and an intricate relationship exists among these diseases, which involves immune, skin barrier and environmental factors 22,23,24

As adjuncts to calorie-restricted diets

Overproduction of carnitine monooxygenase subunits CntA and CntB, MSA-DH, MDH and BCCT resulted in a strain that was able to grow slowly on L-carnitine as the sole carbon and energy source (Supplementary Figure S6)

The immunoregulatory effect of myoinositol combined with Se on CXCL10 indicated that it could reduce the immune response of the body (50)

Overall, analysis of the mice gut microbiome bacteria compositions supported that dysbiosis may play a role in the establishment and progression of disease in the chronic rotenone mouse models by mechanisms such as dysregulated glucose/lipid metabolism and inflammation