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Recently, Lozano and collaborators demonstrated that in melanoma patients treated with anti-PD-1 or anti-PD-1 and anti-CTLA-4 combination, two pretreatment factors in peripheral blood - activated CD4 memory T cell abundance and TCR diversity - were associated with severe irAEs development (79)

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M281, an Anti-FcRn antibody: pharmacodynamics, pharmacokinetics, and safety across the full range of IgG reduction in a first-in-human study

About this article Cite this article Hafezi, M., Arabipoor, A., Ghaffari, F

Aside from this, the disease itself may lead to anemia, renal dysfunction, and hyperviscosity, exacerbating these cardiovascular symptoms