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Tissue-level deficiency of cobalamin is associated with an increase in the urinary and serum concentrations of an organic acid called methylmalonic acid, which is an alternative product of a cobalamin dependent pathway within the mitochondria

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Experimental Applications Research applications include gastric and intestinal mucosal healing models, tendon-to-bone healing studies, muscle crush injury recovery, bone fracture repair, nerve regeneration assays, vascular protection after ischemia-reperfusion injury, and NSAID-induced gastroprotection studies

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Decreased cAMP levels decrease HSL [64] and perilipin-1 [65] phosphorylation