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SG performed the protein alignments and provided the Figure 1

J Biol Chem 289:3584935857 Chen CD, Podvin S, Gillespie E, Leeman SE, Abraham CR (2007) Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

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Additionally, the trial reported renal-related adverse events, including serious adverse events, at a higher rate compared to the placebo group

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Therefore, despite the formation of new blood vessels, the oxygen supply in the joint cavity is not enough to alleviate the hypoxia of the joint cavity, so that the joint cavity is still in a state of hypoxia, which further aggravates the pathological process of RA