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However, it is the chronic cardiotoxicitymanifesting as dilated cardiomyopathy and congestive heart failurethat poses the greatest long-term concern, especially when cumulative doxorubicin doses exceed 450550 mg/m

Other pro-oxidant enzymes include NADPH oxidase (NOX/DUOX), lipoxygenase (LOX), cyclooxygenase (COX), and nitric oxide synthase (NOS), among others [19]

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Allergy Some patients may experience mild allergic reactions to anaphylaxis

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This is the first randomized clinical trial of GlyNAC supplementation in older humans, and it found that a wide variety of age-associated abnormalities improved in older adults supplemented with GlyNAC, while no improvements were seen in those receiving placebo, said corresponding author Dr