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Also, interaction between PRMT5 and SAPs can be targeted by BRD0639 and blocking this interaction reduced PRMT5 function and perturbed cellular growth in MTAP -negative cell lines in vitro (90)

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Overman MJ, Yothers G, Jacobs SA, Sanoff HK, Cohen DJ, Guthrie KA, Henry NL, Ganz PA, Kopetz S , Lucas PC, Blanke CD, Hong TS, Wolmark N, Hochster HS, George TJ, Rocha Lima CMSP

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