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Interestingly, PD is also associated with iron overload and lipid peroxidation, which are highly consistent with ferroptosis, a form of regulated cell death that is initiated by iron-dependent phospholipid peroxidation (4)

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Preclinical Research in Musculoskeletal Models A 2024 musculoskeletal healing narrative review summarized decades of preclinical work and acknowledged the breadth of laboratory findings

In conclusion, compared to normal cells, tumor cells exhibit a significantly higher ratio of de novo synthesized fatty acids, and this metabolic shift is positively correlated with tumor malignancy (62)

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Although the influence of sex hormones on the HPA axis is well-documented, several gaps remain