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The fluorescence signal of FITC and phycoerythrin channel were read using flow cytometry or confocal microscope

Finally, it could provide evidence of target engagement in clinical trials, in the way that beta-amyloid tracers showed unequivocally for anti-amyloid therapies 17

Functions identified to date include cell apoptosis, DNA damage response and alterations of these septin scaffolds, by mutation or expression changes, have been associated with a variety of neurological diseases such as AD and Parkinsons disease (PD) [46,47]

Complications remain rare at 1-2%

Metabolic Syndrome: A post hoc analysis revealed that patients achieving 15% weight loss had a significant decrease in the prevalence of metabolic syndrome, from 8091% at baseline to 2028% at Week 40/52

Maria Serrat reports grants from National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health and grants from National Institute of General Medical Sciences, during the conduct of the study