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The same researchers conducted a larger intervention in 42 children with autistic disorder who had evidence of reduced methylation capacity or GSH:GSSG in which they were supplemented with folinic acid and methyl-cobalamin for 3 months [48]

Zhang, Y., Verwilligen, R

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Vasogenic edema arises from disruption of the BBB and the concurrent ion and plasma protein transfer to the extracellular matrix, and results in accumulation of extracellular water