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The time from the activated state to the inactivated state is the most important, and the activation of channels for a longer time or longer time required from the activated state to the inactivated state is the main cause of imbalance in excitatory and inhibitory pathways that leads to epilepsy and other neurological disorders

Logroscino G, Tortelli R, Rizzo G, Marin B, Preux PM, Malaspina A

[50] [53] The extracellular ligand-binding pocket is closed by a flexible "lid," and the intracellular region includes a short helix (H8) stabilized by -stacking interactions, both of which contribute to the receptor's dynamic conformational landscape

Rouhier, N., Unno, H., Bandyopadhyay, S., Masip, L., Kim, S.K., Hirasawa, M., Gualberto, J.M., Lattard, V., Kusunoki, M., Knaff, D.B., et al

Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide

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