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43 One RCT evaluated B12 alongside anti-depressants in patients with depression and moderately low B12 status (190300 ng/l) and found that 100% of those on B12, 1000 g per week i.m

NNMT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to nicotinamide, influencing intracellular nicotinamide availability and interacting with NAD-associated metabolic processes

Many providers customize their formulations by adding vitamin B12 for energy support or other B vitamins

These are single injections every 2-3 months to keep everything topped up, typically costing between 30 and 70 each

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OBES SURG 32 , 35613570 (2022)