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KOR inhibition of glutamate transmission in NAc MSNs is lost in animals with 5 days of repeated cocaine exposure with at least up to 2 weeks of withdrawal (Mu et al., 2011)

It is important to consult with a healthcare professional before beginning any new treatment

Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired

Because not all systemically administered endogenously occurring neurosteroids readily cross the BBB and because these compounds can be metabolized to hormonally active steroids with different mechanisms of action, the therapeutic potential of these compounds is limited

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Research shows that 80% of subjects who experience severe nausea at 2.4mg tolerate 1.2mg long-term