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Together, these perspectives indicate that future AMS research should prioritize well-powered, mechanistically informed randomized trials, integration of redox and inflammatory biomarkers, and the exploration of multi-target antioxidant strategies that better reflect the complex pathophysiology of altitude illness

This work systematically evaluated the influences of PHD on land occupation, water use, GHG emissions, cumulative energy demand (CED), and nitrogen and phosphorus cycles (Fig

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NNMT is highly expressed in adipose tissue and plays a role in cellular methyldonor economy and nicotinamide processing