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(5) While Fragment 176-191 was suggested to exert its potential action for weight loss via peripheral mechanisms, the aforementioned observation in the review are related to the apparent central action of peptides like Mod GRF 1-29 and Ipamorelin on the pituitary gland

The commercial cosmetic use does not constitute approval of the compound as a medicine and does not establish efficacy claims at the level of evidence required for pharmaceutical regulation

The inactivation of scavenger enzymes by H 2 O 2 represents a mechanism that allows the selective enrichment (flooding) of a cellular area by H 2 O 2 thereby promoting the H 2 O 2 -mediated oxidation of specific thiols within target proteins at this site [22, 23]

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doi: 10.1111/cas.13010 157 MayerE

This does not automatically invalidate the findings, but it is important context