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In ongoing therapy rather than recovery, using both simultaneously is less common

One way to circumvent this problem is the delivery of therapeutic genes encoding intracellular enzymes for the conversion of a prodrug to a cytotoxic drug which can then spread to neighboring non-transduced cells (bystander effect)

Expert Rev Neurother (2018) 18:8390

The green tea polyphenolic catechin epigallocatechin gallate and neuroprotection

In M population, the decrease in cyclotide production under heavy metal stress may be explained the reallocation of resources towards other tolerance mechanisms (e.g., metal sequestration or callose production), while in NM population, the increase in cyclotide production suggests an inducible defense response to mitigate oxidative stress or cellular damage caused by heavy metals

The F-actin binding protein, phalloidin, served as an IS-specific marker in this study