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The oscillatory secretion of sex hormones and thyroid hormones plays a vital role in the regulation of reproductive function and basal metabolic rate, thereby maintaining reproductive health and energy balance (55,56)

For adults, a vitamin B12 level above 300 pg/mL is an ideal level

*Correspondence: ngela Roco, Laboratory of Chemical Carcinogenesis and Pharmacogenetics, (CQF), Molecular and Clinical Pharmacology Program, ICBM - Insituto de Ciencias Biomdicas, Faculty of Medicine, University of Chile, PO Box 70111, Carlos Schachtebeck 299, Quinta Normal, Santiago, Chile e-mail: [email protected] This article was submitted to Pharmacogenetics and Pharmacogenomics, a section of the journal Frontiers in Genetics