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First results from the Phase 1 study of APL-4098, an oral potent GCN2 inhibitor for the treatment of relapsed/refractory acute myeloid leukemia (R/R AML) and myelodysplastic syndromes (MDS)/AML

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Results: Human liver slices in contact with MEECs exhibited greater viability than slices exposed to acellular matrices (ATP/Protein, 1.40.5 pmol/g vs 1.90.5, p 0.8)

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doi: 10.1016/j.cmet.2015.08.024 10 HoffmanDRCornatzerWEDuerreJA

Excess methionine suppresses the methylation cycle and inhibits neural tube closure in mouse embryos