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Many of these placebo-controlled studies have demonstrated that folic acid supplementation improved symptoms in severely depressed patients, elderly depressed and demented patients, and those with major acute depression or schizophrenia, particularly in individuals with RBC folate levels below 453 nmol/L (46)

80 However, the knockout of GPX4 alone is insufficient to induce ferroptosis, indicating the presence of compensatory pathways

It has also been reported that estrogen regulates iron homeostasis by regulating the expression of hepatic hepcidin via an estrogen response element (Hou Y

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