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In contrast, in macrophage-like cells, synthetic ICA derivatives (at concentrations of 10.821.6 M) elicit a distinct response: within 4 hours of exposure, they activate endosomal TLR3 and surface TLR4 (164), triggering cascades of type I interferons (e.g., IFNB1) and proinflammatory cytokines (e.g., IL6, IL12A/B) that amplify innate antiviral immunityunderscoring ICAs context-dependent functional plasticity

Nat Med (2003) 9:4318

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Furthermore, in line with the recent elucidation of the mechanism by which fumarate accumulation in these cells induces epithelial-to-mesenchymal-transition (EMT) 40 , the protein expression data showed a clear EMT signature exemplified by downregulation of E-cadherin ( Cdh1 ) and epithelial cell adhesion molecule ( Epcam ), as well as upregulation of vimentin ( Vim ) (Fig

All analysis is based on publicly available information