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Mitochondria are also involved in apoptosis through the extrinsic pathway, in which the death-inducing signaling complex is formed, leading to activation of caspase-8 and then downstream caspases that target substrates leading to programmed cell death (Vakifahmetoglu-Norberg et al., 2017)

J., Lo Bello, M

Glutaminase is actively expressed in periportal liver cells, renal epithelial cells, and the central nervous system, which is used to synthesize urea and neurotransmitters

Biofloc technology (BFT) in shrimp farming: past and present shaping the future

However, when these conditions remain unresolved, the UPR switches to proapoptotic and inflammatory pathways with persistent accumulation of misfolded proteins promoting cell death ( Indeed, NTZ and its active circulating metabolite tizoxanide directly protect from stress-induced apoptosis and necroptosis to alleviate liver damage in acute-on-chronic liver failure rat model ( Apoe / mice ( In our attempt to scrutinize the hepatoprotective potential of NTZ and the possible implication of ER stress inhibition in our model of MTX-induced hepatotoxicity, we compared NTZ effects to a hepatoprotective NAC with documented ER stress inhibition and with a standard ER stress inhibitor (4-PBA) (Soliman et al., 2019)

ISBN 978-3-642-00662-3