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NAD+ is central to the mechanism

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To investigate the role of ROS and the mechanism of action of DPI in MNA cells, we employed a widely and commercially available mitochondria-targeted antioxidant, mitoquinone mesylate (MitoQ)

Sigmoidal dose-response curves and reliable estimates of IC 50 values based on non-linear least-squares fitting to the available data could not be obtained since no significant inhibition of DNMT1 and PRMT3 was observed at the tested NNMT inhibitor concentrations (Table 3)

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