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In this study, the authors used PTZ-induced epileptic rats as an epilepsy model and used a specific dose of 300 mg/kg and compared with the marketed drug diazepam and evaluated by electroencephalographic (EEG) profiling

However, this varies from person to person

PMID: 29948021

showed no modification of [Met 5 ]-enkephalin-induced receptor desensitization on K + channels in locus coeruleus neurons (Arttamangkul et al., The implication of other kinases than GRK and PKC in MOR desensitization was also investigated

The following parameters were measured: left ventricular systolic diameter (LVSd), interventricular septal thickness at systole (IVSs), left ventricular internal diameter at diastole (LVIDd) and systole (LVIDs), and left ventricular posterior wall thickness at diastole (LVPWd) and systole (LVPWs), left ventricular ejection fraction (LVEF), and left ventricular fractional shortening (LVFS)