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While HIF-1 promotes osteoclastogenesis under hypoxia via AMPK signaling (Tang et al., 2020), it also induces apoptosis in osteocytes through the JNK/caspase-3 pathway in vitro , further stimulating osteoclast differentiation by increasing apoptotic bodies (Song et al., 2020)

Mitochondrial reactive oxygen species regulate the induction of CD8(+) T cells by plasmacytoid dendritic cells

Most researchers have paid much more attention to the radicals and their damages in mechanism of action of artemisinin, but not on the fact that heme is consumed by artemisinin and hemozoin formation is interfered

Traditional treatments (topical steroids, biologics, immunosuppressants) target these pathways directly

Research published in the Journal of Endocrinology showed that IGF1 LR3 increased protein synthesis in cultured myotubes by starting the mTOR pathway and enhancing ribosomal protein S6 phosphorylation, a key marker of translational activity

Tran DH, May HI, Li Q, Luo X, Huang J, Zhang G, et al