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During tumor immunotherapy, IFN- released by activated CD8 + T cells also upregulates the expression of ACSL4 in tumor cells through the STAT1-IRF1 signaling pathway [111]

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Peak hepatic injury occurs at 35 days after the toxic ingestion, and hepatic encephalopathy may be evident at this time, along with acute, oliguric renal failure (mechanism unclear), and lactic acidosis (from reduced hepatic clearance) (3)

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