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Description

AMPK activators Systemic metabolic dysregulation has emerged as a pivotal, load-independent driver in the pathogenesis of OA

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However, under conditions of iron overload, excess Fe 2+ in the LIP undergoes Fenton chemistry with H 2 O 2 , producing excessive ROS, promoting lipid peroxidation, and ultimately triggering ferroptosis (Zhao et al., 2025a)

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Tokgzolu, L., & Libby, P

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Elevated protein lactylation promotes immunosuppressive microenvironment and therapeutic resistance in pancreatic ductal adenocarcinoma

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Park YW, Zhu S, Palaniappan L, Heshka S, Carnethon MR, Heymsfield SB

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