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Acetaminophens Complementary Analgesic Mechanism Acetaminophen inhibits cyclooxygenase (COX) enzyme activity in the central nervous system, reducing prostaglandin E2 synthesis and producing analgesia and antipyresis through pathways that do not involve opioid receptor binding

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(C) After transfection with NF-B-luciferase reporter in RAW264.7 macrophages, the RAW264.7 cells were incubated with Sch A or Sch B, as described in Materials and Methods